Drugs used in treatment of Angina Pectoris

  1.   In effort and variant angina predominantly are useful?

  1. Beta-adrenoceptor blockers;

  2. Calcium channel blockers;

  3. alfa-adrenoceptor blockers;

  4. ACE inhibitors.


  1.   Effort angina may occur when:

  1. Oxygen demand increases;

  2. Coronary artery reversibly constricts;

  3. Episodes of angina occur at rest and when there is a change in the character, frequency, and duration of chest pain;

  4. Transient spasm of localized portions of the vessels is usually associated with underlying atheromas.


  1.   Nitrates toxicities does not include:

  1. Orthostatic hypotension;

  2. Tachycardia;

  3. Headache;

  4. AV blockade.


  1.   Nitroglycerin increases the concetration of nitric oxide (NO) in vascular muscle cells and causes an increase in:

  1. cAMP (cyclic adenosine monophosphate);

  2. cGMP (cyclic guanosine monophosphate);

  3. IP3 (inositol-1,4,5-triphosphate);

  4. DAG (diacylgycerol).


  1.   Tolerence may be caused by a decrease in tissue sulfhydryl groups during action of:

  1. Verapamil; 

  2. Nifedipine;

  3. Nitroglycerine;

  4. Metoprolol.


  1.   Beneficial effects of nitrates in the treatment of angina pectoris include:

  1. Decreased ventricular volume;

  2. Reflex tachycardia;

  3. Reflex increase in contractility;

  4. Decreased diastolic perfusion time.


  1.   Unwanted effects of nitrates in the treatment of angina pectoris include:

  1. Decreased left ventricular diastolic pressure;

  2. Increased collateral flow;

  3. Vasodilation of epicardial coronary arteries;

  4. Reflex tachycardia.


  1.   Calcium channel blockers may be used, except:

  1. For prophylaxis of effort angina;

  2. For prophylaxis of variant angina;

  3. In vasospastic angina for prevention of coronary spasm;

  4. Acute coronary syndrome, because they have little or no benefit.


  1.   Calcium channel blockers act in effort angina by:

  1. Causing peripheral vasodilation;

  2. Reduction of preload;

  3. Increasing of cardiac work;

  4. Increase coronary vasospasm.


  1.   Short-acting nitrates include:

  1. Isosorbid dinitrate (oral);

  2. Transdermal nitroglycerin;

  3. Isosorbid mononitrate (oral);

  4. Nitroglycerin (sublingual).


  1.   The beneficial effects of beta-blocking agents in angina pectoris are related to, except:

  1. Decreased heart rate;

  2. Reduced heart contractility;

  3. Increased end – diastolic volume and ejection time;

  4. Decreased myocardial oxygen consumption.


  1.   Beta-adrenoceptor blockers are not effective in:

  1. Variant angina;

  2. Arterial hypertension;

  3. Effort angina;

  4. Acute coronary syndrome.


  1.   Beta-adrenoceptor blocking agents are not vasodilators, with the possible exception of:

  1. Propranolol;

  2. Nebivolol;

  3. Metoprolol;

  4. Bisoprolol.


  1.   Contraindications to the use of B-adrenoceptor blockers are:

  1. Heart failure (II functional class);

  2. Arterial hypertension;

  3. Asthma;

  4. Effort angina.